Lecture Slides
Topic |
Slides/Reading/Links |
| Welcome and Introduction to Molecular Biology (1/17, 1/19) | Slides, Chapter 2, DNA Replication, Transcription/Translation |
| PCR, Sequencing, and Sequence Alignment (1/24, 1/26, 1/31) | Slides, Sections 6.4, 6.6, 6.7, 6.8 |
| "Classic" Shotgun Sequence Assembly (2/2, 2/7) | Slides, Sections 8.1--8.4 |
| Gene Prediction, Spliced Alignment, and Motif Finding (2/9, 2/14, 2/16) | Slides, Spliced Alignment Paper, Sections 6.11, 6.14, 4,6--4.8 |
| Hidden Markov Models for Sequence Analysis (2/14) | Slides, Chapter 11 |
| Multiple Sequence Alignment and Phylogenetic Trees (2/21, 2/23) | Slides |
| High-Throughput Sequencing and Applications (3/7, 3/9) | Slides, Wooly Mammoth Reconstruction, Engineering Genetic Defects, CRISPR/Cas9 |
| Introduction to Protein Structure (3/14, 3/16) | Slides |
| Secondary Structure Prediction Methods (3/21) | Slides |
| Algorithms for Protein Structure Comparison (4/4, 4/6) | Slides |
| Tertiary Structure Prediction (4/11, 4/13) | Slides |
| Experimental Structure Determination and Drug Design (4/18, 4/20) | Slides |
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